Ultrashort TE enhanced T 2 * mapping of cartilage : A Pilot Clinical Study
نویسنده
چکیده
Introduction This clinical report assesses the feasibility of 3-D ultrashort echo time enhanced T2* (UTE-T2*) mapping of cartilage in vivo and examines the sensitivity of UTE-T2* to early cartilage degeneration compared to arthroscopic grading as the standard. UTE-T2* mapping is sensitive to changes in short-T2 signal (T2 <10ms) and may provide improved sensitivity to subtle matrix alterations, particularly in deep layers, that are not well captured by standard T2 mapping. A previous in vitro study indicated that UTE-T2* values reflect cartilage collagen matrix structural integrity as determined by polarized light microscopy. We hypothesize that UTE-T2* mapping in vivo is sensitive to earlier degenerative changes of articular cartilage than can be detected with standard T2.
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